THU0237 MUSCLE ARCHITECTURE IN PATIENTS WITH SJÖGREN’S SYNDROME

Background Although fatigue and skeletal muscle involvement is not rare in Sjogren’s Syndrome (SS) patients, there is not much data about the macroscopic structure of the skeletal muscle. Objectives 1) To investigate if ultrasonographic muscle architecture and muscle strength differed in SS patients 2) To investigate if these changes correlated with disease activity, fatigue, anxiety and depression. Methods Assuming 2.40 mm mean difference and 2.5 mm SD of thickness at vastus lateralis muscle with 80% power and 5% significance 19 SS patients and 19 healthy controls (HCs) were recruited (1). Disease activity was measured by EULAR Sjogren Disease Activity Index (ESSDAI), anxiety and depression were assessed with the Hospital Anxiety and Depression Scale (HADS), fatigue with Multidimensional Assessment of Fatigue scale (MAF), quality of life with Health Assessment Questionnaire (HAQ). A single rheumatologist, blind to the participants’ group assignment, performed the ultrasonographic evaluation using a multi-frequency linear probe. Thickness of bilateral quadriceps femoris, gastrocnemius and soleus muscles, pennation angle and fascicle length was measured. Isokinetic knee and ankle muscle strength tests were performed at 60- 180°/s and 30- 120°/s respectively by a calibrated isokinetic testing machine. Results Patients with SS scored higher than HCs for depression, anxiety, quality of life and fatigue (p Conclusion Patients with SS have some minor structural changes on ultrasonographic evaluation. Although there was no difference in isokinetic muscle strength measurements between groups, knee strength and endurance had a moderate negative correlation with disease activity in SS patients. Reference [1] Kaya A, et al. Ultrasonographic evaluation of the muscle architecture in patients with systemic lupus erythematosus. Clin Rheumatol2013; 32: 1155-1160. Disclosure of Interests None declared