Relationship of plasma anti-heparin activity and platelet survival time in coronary disease

Abstract Platelet-endothelial interaction probably plays a role in the development of atherosclerotic vascular disease and its complications. Platelet survival time has been found to be shortened and plasma anti-heparin activity has been shown to be increased in patients with coronary atherosclerosis. Platelet survival (autologous labelling with 51 Chromium) and plasma anti-heparin activity (heparin-thrombin clotting time of platelet poor plasma) were measured in 75 men with coronary artery disease. Platelet survival was shortened (