Assessment of Wound Therapy Systems.

Abstract : The project goal is the development of a wipe-on burn covering which stores easily, applies readily, adheres for several days, and peels off without trauma. A wipe-on system consisting of a polycaprolactone polymer was developed. Two water-based film forming systems were investigated. More recently, work has focused only the PViPAA system, because it appears to be quite biocompatible and does not pose the threat of antigenicity, which is a concern in the use of gelatin. In Section 2, this report covers five areas of study of PViPAA not reported earlier: effects of pH on PViPAA gels, effects of salinity on PViPAA gelation, absorption/resorption of bovine serum albumin on PViPAA gels, effects of some additions to PViPAA gels, and release of antibiotics from PViPAA gels. A new material derived from PViPAA is described in Section 6. An evaluation of a PViPAA covering on an excision wound is given in Appendix B.