Levetiracetam in the treatment of neonatal seizures.

Levetiracetam has properties which make it a promising candidate for the treatment of neonatal seizures. The mechanism of action and evidence of broad spectrum clinical efficacy in adults and older children is reviewed along with the limited reported experience in neonates. The safety profile, pharmacokinetic properties and evidence of neuroprotective qualities are discussed together with the current status of pharmacokinetic studies in neonates.