Visualization of Apoptosis: Annexin V Imaging

Annexin V, a human protein with nanomolar affinity for cell membrane-bound phosphatidylserine (PS), is the most widely used conjugate for the detection of apoptosis by using the imaging modalities such as SPECT, PET, MRI, and optical imaging. This chapter will initially focus on the most recent reports on annexin V-conjugated imaging agents in both animals and humans, followed by conclusions and the possible future directions of annexin V imaging.