Effect of the pharmacological antagonism of the endocannabinoid receptors on the sodium balance in liver cirrhosis

The endocannabinoids are endogenous mediators implicated in many physiologic and pathophysiologic processes. It has been recently shown that they contribute to the pathogenesis of liver fibrosis and hemodynamic alterations of cirrhosis. The pharmacological modulation of the endocannnabinoid system represents a potential target for the treatment of liver diseases.