STUDY OF FRESH AUTOLOGOUS PERICADIAL VALVE IN ABDOMINAL AORTA AS HEART VALVE SUBSTITUE MATERIAL

Objective To study the fresh autologous pericardial valve in abdominal aorta as heart valve substitute.Methods Fresh and 2 g/L glutaraldehyde-treated autologous pericardial valve(each group,n=8) was implanted into swine abdominal aorta.When the pericardial valves were harvested at 3(T1) and 6(T2) months after the surgery(each time in each group,n=4),with macroscopic and histological inspection,as well as observation under electron microscope,we studied the valves' expansibility,biocompatibility and calcification.Results There is a single layer of endothelial-like cell on the surface of all the pericardial valves and thrombus inside the valves.The connection between fresh autologous valves and aortic tissue is tighter,with positive expansion in their length than when implanted(F=223.44;q=3.73,3.86;P0.05).Moreover,the increase of calcification in fresh valves is lower than treated ones(t=14.969,19.204;P0.05).Conclusion Fresh autologous pericardial valves have great potential as heart valve substitute,and will be especially useful in surgical treatment for heart valve disease in children.