A phase I/II study of hydroxychloroquine and suba-itraconazole in men with biochemical relapse of prostate cancer (HITMAN-PC): Dose escalation results.

Brandon Lau,Megan Crumbaker,Andrew On Wah Yam,Stefano Marastoni,Mathew Luckhurst,Aaron OGrady,Brad Wouters,Anthony M. Joshua

A phase I/II study of hydroxychloroquine and suba-itraconazole in men with biochemical relapse of prostate cancer (HITMAN-PC): Dose escalation results.

2021

Brandon Lau
Megan Crumbaker
Andrew On Wah Yam
Stefano Marastoni
Mathew Luckhurst
Aaron OGrady
Brad Wouters
Anthony M. Joshua

114Background: Preclinical data show hydroxychloroquine (HCQ) and suba-itraconazole (SI) together enhance prostate cancer cell death. The proposed mechanism is lysosome dysfunction including seques...

Keywords:

dose escalation
Oncology
Prostate cancer
Hydroxychloroquine
preclinical data
Lysosome
SUBA-Itraconazole
phase i ii
Medicine
Internal medicine
Biochemical relapse

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