Regulation of Thymic Stromal Lymphopoietin (TSLP) Receptor Expression

Objective/purpose TSLP plays a major role in the induction and effector phases of allergic diseases by acting on dendritic cells, mast cells (MCs), T cells and CD34 hemopoietic progenitor cells. Whereas the cellular origin and the mechanisms regulating TSLP production are well documented, little is known about the regulation of TSLP receptor expression. We analyzed the regulation of TSLP-R with several cytokines, TLR ligands and drugs commonly used to treat asthma.