C-H-Activation approach in the synthesis of palonosetron core: A 5-HT3 receptor antagonist

Intramolecular rhodium (III) catalyzed annulation of benzamide 8 has been described in the efficient synthesis of palonosetron core, 5-HT3 receptor antagonists. C–H-activation enabled the simultaneous generation of rings B and C, which can further be functionalized to access a series alkaloid.