Method development and validation for simultaneous determination of Telmisartan and Ramipril by UV Spectrophotometry

A simple, validated, accurate and precise simultaneous UV Spectrophotometric method has been developed for the simultaneous estimation of Telmisartan (TEM) and Ramipril (RAM) in pharmaceutical dosage form. Telmisartan exhibits absorption maximum at 254.4nm and Ramipril shows absorption maximum at 209nm in methanol. The Beer’s law obeyed the concentration range of 2-12µg/ml for both TEM and RAM. Mean recovery of 99.14% for TEM and 99.05% for RAM respectively signifies the accuracy of the method. The method was validated as per ICH guidelines. The method shows good linearity, accuracy, precision, limit of detection and limit of quantification. This method can be successfully employed for the routine simultaneous estimation of TEM and RAM in pharmaceutical dosage forms. Keywords: Telmisartan, Ramipril, Estimation, Spectrophotometry, Dosage form