Ethanol oxidation in the microsomal fraction of rat liver

Abstract The NADPH dependent oxidation of ethanol by the liver microsomal fraction has been investigated. NADPH cannot be replaced by H 2 O 2 but can be replaced by glucose + glucose oxidase in the system. Aminotriazole inhibits the activity but less than it does catalase. It is concluded that ethanol oxidation by the microsomal fraction is mediated through H 2 O 2 dependent systems one of which is catalase.