Usefulness of Mean Platelet Volume and Neutrophil-To-Lymphocyte Ratio for Development of Atrial Fibrillation After Acute Myocardial Infarction

Objective: Atrial fibrillation (AF) is the most common supraventricular arrhythmia following ST elevated myocardial infarction (STEMI). Mean platelet volume (MPV) is an indicator of platelet activation and function. Mean platelet volume has been identified as an independent risk factor for future stroke and myocardial infarction. The neutrophil-to-lymphocyte ratio (NLR), fast and easy method for detecting inflammatory status, have been recently explored as a predictor for cardiovascular risk and AF. The aim of the present study was to evaluate a possible relationship between NLR and MPV levels on development of AF after STEMI. Methods: This prospective study consisted of 743 patients with acute STEMI who were admitted to coronary care unit. Patients were divided into two groups, patients with and without AF. Predictors of AF were determined by multivariate regression analysis. Results: From a total of 743 patients presenting with STEMI, 82 (11%) developed AF. Mean platelet volume and NLR was significantly higher in patients with AF compared to without AF (p<0.001, respectively). Multivariate regression analysis results showed that, age [Odds Ratio (OR)=1.03; 95% Confidence Interval (CI)=1.01-1.05; p=0.001), ejection fraction (OR=0.95; 95% CI=0.93-0.98; p<0,001), MPV (OR=1.738; 95% CI=1.29-2.33; p<0.001), NLR (OR=1.08; 95% CI=1.01-1.15; p=0,025) and previous angiotensinogen converting enzyme blockers (OR=3.04; 95% CI=1.22-7.54; p=0,017) using were associated with development of AF in patients with acute STEMI. Conclusions: This study showed that, MPV and NLR were associated with the development of AF in patients presenting STEMI, other independent predictors of AF included age, and ejection fraction.