1,3-Thiazepines. 1. Synthesis and spectral properties of 2-iminohexahydro-1,3-thiazepines

By reaction of 4-amino-1-butanol with isothiocyanates RNCS, we have synthesized N-(4-hydroxybutyl)-N′-R-thioureas, which by cyclization when treated with hydrohalic acids are converted to the corresponding 2-(R)-imino)hexahydro-1,3-thiazepines. The structure of the compounds obtained has been confirmed by PMR, IR, and mass spectra.