Clinical characteristics and treatment of intracranial hemangiopericytomas

Objective To retrospectively summarize the clinical manifestations,treatment and prognosis of intracranial hemangiopericytomas(HPCs),and to optimize process of diagnosis and treatment.Methods The data of 10 cases of HPCs were reviewed,including their clinical characteristics,imaging display,treatment process,pathology and prognosis.Results The onset lesions included 4 cases in supratentorial falx,3 in middle cranial fcssa,3 in posterior cranial fossa.The tumors grew across the cerebral falx or adjacent venous sinus.The imaging examinations showed that there was no calcification both inside and on margin of the lesions.The adjacent skull could be eroded but there was no thickening.Part of phyllodes tumors were found to be with narrow necks and lack of dural tail signs.All the patients were performed operation,6 cases achieved total removal and 4 subtotal.The pathological examinations after operation showed 7 cases of WHO Ⅱ and 3 WHO Ⅲ.All the recurring cases were WHO Ⅲ in both onset and recurrence lesions.All the cases accepted radiation therapy,and 1 recurring case was given chemotherapy after the removal of relapse lesion.The follow-up period was from 13 months to 137 months (mean duration:62.5 months).There were 2 recurred cases with second surgery and local radiation for metastasis.Conclusions Although HPCs are extremely rare and easily misdiagncsed as meningiomas,there were still some characteristic features in clinical manifestation and imagings.The adjuvant radiotherapy should be given after operation.When the tumor recurrence was confirmed,surgery and radiosurgery,which could be performed repeatedly,should be recommended in order to control the recurrence or metastasis of tumors. Key words: Hemangiopericytoma;  Central nervous system;  Syndrome;  Surgery;  Radiotherapy;  Prognosis