Activity of Childhood Lupus Nephritis is Linked to Altered T Cell and Cytokine Homeostasis

Monika Edelbauer,Sudhir Kshirsagar,Magdalena Riedl,Heiko Billing,Burkhard Tönshoff,Dieter Haffner,Gerard Cortina,Oliver Amon,Sophia Ross,Jörg Dötsch,G. Wechselberger,Lutz T. Weber,Martin Dablander,Markus Anliker,Andrea Griesmacher,Elisabeth Steichen-Gersdorf

Activity of Childhood Lupus Nephritis is Linked to Altered T Cell and Cytokine Homeostasis

2012

Monika Edelbauer
Sudhir Kshirsagar
Magdalena Riedl
Heiko Billing
Burkhard Tönshoff
Dieter Haffner
Gerard Cortina
Oliver Amon
Sophia Ross
Jörg Dötsch
G. Wechselberger
Lutz T. Weber
Martin Dablander
Markus Anliker
Andrea Griesmacher
Elisabeth Steichen-Gersdorf

Purpose Standard therapy for lupus nephritis is based on non-specific immunosuppression. We aimed to identify specific alterations in T cell and cytokine homeostasis and possible associations with disease activity in children with lupus nephritis (LN).

Keywords:

Lupus nephritis
Homeostasis
Immunology
Cytokine
T cell
Immunosuppression
Disease
Diabetes mellitus
Biology
Medical microbiology
Immunophenotyping

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