Abstract P3018: Sirt3 Depletion in Human Essential Hypertension is Linked to Vascular Inflammation and Oxidative Stress While Endothelial Specific Sirt3 Depletion in Mice Promotes Vascular Dysfunction and Increases Hypertension

Anna Dikalova,Arvind K. Pandey,Liang Xiao,Marcos G. Lopez,Frederic T. Billings,Eric Verdin,Johan Auwerx,David G. Harrison,Sergey Dikalov

Abstract P3018: Sirt3 Depletion in Human Essential Hypertension is Linked to Vascular Inflammation and Oxidative Stress While Endothelial Specific Sirt3 Depletion in Mice Promotes Vascular Dysfunction and Increases Hypertension

2019

Anna Dikalova
Arvind K. Pandey
Liang Xiao
Marcos G. Lopez
Frederic T. Billings
Eric Verdin
Johan Auwerx
David G. Harrison
Sergey Dikalov

Hypertension represents a major risk factor for stroke, myocardial infarction, and heart failure and affects 30% of adult population. Vascular dysfunction is crucial in hypertension pathophysiology...

Keywords:

Oxidative stress
Internal medicine
Endocrinology
Inflammation
Diabetes mellitus
SIRT3
Essential hypertension
Medicine
vascular inflammation

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