Factors associated with clinical reactions to rubella vaccination in women

Abstract Two types of rubella vaccine were given to 272 seronegative healthy Japanese adult women. Clinical and laboratory studies on clinical reaction after vaccination were carried out on HI antibody response, HLA types, basal body temperature (BBT), menstrual cycles and serum progesterone levels of vaccinees. Clinical reactions were not associated with HLA types of vaccinees, but arthropathy occured significantly more often in women vaccinated at the progestational stage than in women vaccinated at the estrogenic stage.