The influence of psychotropic drugs on aldolase, mitochondrial malic dehydrogenase and Mg++Na+K+ adenosine triphosphatase

Abstract 1. The experiment investigated the effects of psychotropic drugs on enzymes in vitro. 2. Chlorpromazine inhibits mitochondrial malate dehydrogenase in concentrations of 1·4×10-4M and above. No effect was observed below this concentration. 3. A sharp inflection in the [unk]/drug plot was also seen with chlorpromazine (1·4 × 10-4M), trifluoperazine (1 × 10-5M), prochlorperazine (1 × 10-4M), and amylobarbitone (8 × 10-3M) acting on rat brain (Na+-K+-) Mg++-ATPase and with chlorpromazine (10-4M) and imipramine (3 × 10-4M) acting on aldolase.