Microwave enhanced heterocyclization: A convenient procedure for antimicrobial 1,5-benzothiazepine compounds §

A series of 2,5-dihydro-4-[1'-(o-chlorophcnyl)-3'-methyl-5'-pyrazolidene azomethine]-2-(substituted phenyl)-1,5 benzothiazepines 7a-j have been synthesized using environmentally benign procedure and evaluated for their antimicrobial activity. Neat reactants on microwave irradiation (MWI) under solvent-free-condition resulted in enhancement of yields and reaction rates. Structures of the synthesized compounds have been elucidated on the basis of their elemental analyses and spectral data.