Factores de riesgo para la adquisición y características microbiológicas de las bacteriemias por Acinetobacter baumannii multi-resistente en pediatría: Estudio de casos y controles

Background: Multidrug-resistant Acinetobacter baumannii (MAB) is an important nosocomial pathogen. Objectives: To analyze the risk factors for acquiring MAB, and the clinical and microbiological characteristics of MAB bacteremia (MABB) in children. Materials and Methods: Control-case study 2005-2008. Demographic and clinical data from all MABB and from non-multiresistant gram-negative bacteremias were recorded. Identification at species level, antimicrobial susceptibility tests, time-kill studies and clonally relationships were performed. Stata 8.0 was used for data analysis. Results: A total of 50 MABB and 100 controls were included. Ninety four percent of patients acquired MAB in ICU and the 88% had underlying diseases. All patients had invasive procedures previous to MABB. The median of hospitalization stay previous to MABB was different in cases than in controls (16 vs 7 days, p Introduccion: Acinetobacter baumannii multi-resistente (ABM) es un patogeno intrahospitalario de importancia. Objetivos: Analizar factores de riesgo de adquisicion y caracteristicas clinicas y microbiologicas de las bacteriemias por ABM (BABM) en pediatria. Metodos: Estudio de casos y controles periodo 2005-2008. Se incluyeron variables demograficas y clinicas de pacientes con BABM y por otros bacilos gramnegativos no ABM. Se realizaron pruebas para identificacion de especie, susceptibilidad antimicrobiana y deteccion feno-genotipica de mecanismos de resistencia, sinergia y clonalidad. Analisis estadistico: Stata 8.0. Resultados: Se incluyeron 50 BABM y 100 controles. El 94% de los pacientes adquirieron la BABM en UCI y 88% tenia patologias subyacentes. La mediana de dias de internacion previa a la bacteriemia fue mayor en los casos (16 vs 7 dias, p