Correlation of yroid Profile and Lipid profile in Metabolic Syndrome patients

Objective: The aim of our study is to assess thyroid function tests in patients with Metabolic Syndrome and to find a correlation between hypothyroidism and lipid profile in metabolic syndrome. Study Design: A hospital based cross sectional study was conducted on patients attending the OPD of Medicine of GSVM Medical College, Kanpur (U.P) for a period of 10 months from January 2015 to October 2015. Atotal no. of 100 cases of Metabolic syndrome in the age group 30-60 yrs (According to IDF consensus 2006) were selected randomly for the study. Above 60 yrs and below 30 yrs were excluded from our study. Besides patients having any chronic illness such as TB, Carcinoma’s and patients on lipid lowering drugs were excluded from this study. Methodology: All the 100 subjects were analyzed for Serum T3, Serum T4, Serum TSH and lipid profile. Samples were collected in fasting state and Sr. T3, T4 & TSH were estimated using ELISA competitive immunoassay method. Total Cholesterol & HDL Cholesterol were determined by enzymatic methods. LDL & VLDL were calculated and TG was estimated by an analytical method. Statistical analysis was done & results expressed in Mean±SD±SE. Results: Out of 100 cases of Metabolic Syndrome, 20 were of Subclinical hypothyroidism, 7 had overt Hypothyroidism & 73 patients were Euthyroid. Among these patients Hypertriglyceridaemia, hypercholesterolaemia, raised LDL and low HDL was found in overt hypothyroidism, Subclinical hypothyroidism and to some extent in Euthyroid cases.