Tricyclic azepines and diazepines bi- and n-bifenilcarbonil- and n-fenilpiridilcarbonil substituted as vasopressin agonists.

2002 
Use of a compound of formula (I) or (II): wherein: Y is selected from NR or moiety - (CH2) n: wherein R is hydrogen or (C1-C6), and n is 1; represents: (1) a phenyl ring optionally substituted with one or two substituents independently selected from hydrogen, (C1-C6), halogen, cyano, CF3, hydroxy, (C1-C6) -alkyl, (C.sub.1 -C.sub.6) alkoxycarbonyl , carboxy, -CONH2, -CONH [alkyl (C1-C6)] and -CON [(C1-C6)] 2; or (2) an aromatic heterocyclic ring is 6-membered nitrogen atom, optionally substituted with (C1-C6), halogen or (C1-C6); represents: (1) a phenyl ring optionally substituted with one or two substituents independently selected from hydrogen, (C1-C6), halogen, cyano, CF3, hydroxy, (C1-C6), or alkoxy (C1-C6) carbonyl, carboxyl, -CONH2, -CONH [(C1-C6)] and -CON [(C1-C6)] 2; or (2) an aromatic heterocyclic ring is 5-membered nitrogen atom, optionally substituted alkyl (C1-C6) alkoxy (C1-C6) or halogen; or (3) an aromatic heterocyclic ring is 6-membered nitrogen atom, optionally substituted with (C1-C6), halogen or (C1-C6); represents an aromatic heterocyclic ring (unsaturated) 5-membered has a sulfur atom, optionally substituted with (C1-C6), halogen or (C1-C6); R1 is a radical of formula and R2, R3, R7, R8 and R9 are independently selected from hydrogen, (C1-C3), OCH3, halogen, CF3, -SCH3, OCF3, SCF3 and CN; or a pharmaceutically acceptable salt thereof, in the preparation of a medicament for the treatment of a disorder which is remedied or alleviated by the activity of a vasopressin agonist in a mammal, selected from the group of diabetes insipidus, nocturnal enuresis, nocturia, incontinence urinary and temporary delay urination.
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