A Comparison of 5-Fluorouracil Administered by Slow Infusion and Rapid Injection

A comparison of 5-fluorouracil administered by rapid i.v. injection versus 2-hr infusion was conducted in a double-blind study of 149 patients with advanced large bowel cancer. Dosages for each regimen were selected to produce definite but clinically tolerable toxicity. Toxicity pattern, objective response, and symptomatic response were essentially equal with these methods of administration. For practical reasons the rapid injection method is preferred.