Delayed graft function in patients treated with sustained low-efficiency daily dialysis

Objective To observe the effect of sustained low-efficiency dai1y dialysis (SLEDD) in recipients with delayed graft function (DGF) after kidney transplantation. Methods A total of 78 cases of kidney transplant patients with DGF were selected from the Department of Renal Transplantation of the First Affiliated Hospital of Xi’an Jiaotong University from June 2011 to March 2016. 22 cases were treated with intermittent hemodialysis(IHD), 32 cases were treated with SLEDD and 24 cases were treated with continuous veno-venous hemofiltration(CVVH) randomly in other 56 cases. No statistical difference was found in the clinical data of the three groups(P>0.05). Data of uremic toxin’sclearance, hemodynamics, water-electrolyte and acid-base balance, disease outcome indicators, time and cost of blood purification were analyzed retrospectively. Results The average uremia toxin’s concentration changes per treatment of IHD group were more significant than those of SLEDD and CVVH groups (P 0.05). Electrolyte and acid-base indicators of the three groups were no statistical significance(P>0.05). The expenses of blood purification ofCVVH group were significantly higher than those of IHD and SLEDD group (P 0.05). Conclusions Compared with IHD therapy, SLEDD treatment in DGF patients could reach higher hemodynamic instability and graft function recovery rates, shorter recovery time, and relatively larger fluid intake space. Compared with CVVH therapy, SLEDD treatment needed relatively fewer blood purification treatment time and cost, but had no obvious difference about uremia toxin’s clearance rates, hemodynamic instability, renal function recovery rates and recovery time. Key words: Delayed graft function; Kidney transplantation; Sustained low-efficiency dai1y dialysis; Continuous veno-venous hemofiltration; Intermittent hemodialysis