BIOCHEMICAL CHANGES DURING PHYSICAL EXERCISE IN JUVENILE DIABETICS

1975 
11 boys with diabetes (dia) 9–16 yrs old and 9 boys with small stature /sm) 9–14 yrs old were given a three step 30 min work load on a bicycle ergometer, the last step being near the maximal work load (15–20 kpm/kg). The mean physical working capacity at pulse rate 170 was 12.7 ± 3.4 kpm/min/kg in the dia and 11.3±2.1 in the sm. Maximal O2 consumption was 43.5±6.4 ml/kg/min in the dia and 43.61±12.9 in the sm. Biochemical parameters were measured before, during and after exercise. The mean relative increase of plasma glucose was 9.81±12.6% in the dia and 11.4±11.5% in the sm. Blood lactate rose 2.32±0.98 mMol/1 in the dia and 2.32±2.32 in the sm. Free fatty acids changed similarly in both groups. Plasma growth hormone rise was 22.7±11.0 ng/ml in the dia and 20.7±15.3 in the sm. Plasma cortisol changes were small. The rise of urinary epinephrine and NOR epinephrine was similar in both groups. All metabolic changes were not significantly in the two groups and the strenuous exercise had no untoward effects in any of the patients.
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