Role of NF-E2 Related Factor (Nrf2) in Hyperoxic Lung Injury: Implications for Bronchopulmonary Dysplasia and Acute Respiratory Distress Syndrome

Hyperoxia contributes to the development of bronchopulmonary dysplasia. Reactive oxygen species (ROS) play an important role in the molecular mechanism of oxygen mediated lung injury. Innate anti-oxidant mechanisms in the cells play an important role in the protection against oxygen toxicity and recent studies have suggested that genetic variants (e.g. single nucleotide polymorphism (SNP) of …