PULSATILE DRUG DELIVERY SYSTEM: A REVIEW PULSATILE DRUG DELIVERY SYSTEM: A REVIEW PULSATILE DRUG DELIVERY SYSTEM: A REVIEW PULSATILE DRUG DELIVERY SYSTEM: A REVIEW *R. As

Pulsatile Drug Delivery Systems are gaining a lot of interest as they deliver the drug at the right place at the right time and in the right amt. hence providing temporal delivery and in creasing patient compliance. Pulsatile drug delivery systems are designed according to the circadian rhythm of the body. Thus the principle rationale for the use of pulsatile release of the drugs is where a constant drug release is not required. A pulse has to be designed in such a way that a complete and rapid drug release is achieved after the definite lag time. Pulsatile systems are beneficial for the drugs having chronopharmacological behavior where night time dosing is desired, such as antiasthmatic, antihypertensive and antiarhythmic. Current review article discussed the development of pulsatile drug delivery system, types of disease in which pulsatile release is required, advantages, disadvantages, classification, limitation, evaluation and work done on pulsatile drug delivery system.