Studies on Total Syntheses of Antitumor Styryllactones: Stereoselective Total Syntheses of (+)-Goniofufurone, (+)- Goniobutenolide A, and (-)-Goniobutenolide B.

Abstract A highly stereoselective aldol reaction of the aldehyde 11, derived from (+)-tricarbonyl(η6-2-trimethylsilylbenzaldehyde)chromium(0) complex (4), with 2-trimethysilyloxyfuran afforded the γ-lactone derivative 13. The γ-lactone 13 was subsequently converted into three antitumor styryllactones, (+)-goniofufurone, (+)-goniobutenolide A, and (−)-goniobutenolide B.