N-Heterocyclic Carbene-Catalyzed Asymmetric Benzoin Reaction in Water
2018
A chiral N-heterocyclic carbene-catalyzed benzoin condensation reaction in water has been developed, affording α-hydroxy ketones in good to high yields and high enantioselectivities. Water was proposed as a proton shuttle in the aqueous asymmetric condensation reaction.
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