Genomic DNAs involved in rheumatoid arthritis, procedure for diagnosis, estimation procedure and its appearance diagnosis kit for detection.

A genomic DNA involved in rheumatoid arthritis, comprising at least one of the following mutations in genomic DNA consisting of the base sequence of SEQ ID NO 1: 1) substitution of thymine (t) for cytosine (c) the 1987 position; 2) substitution of guanine (g) for thymine (t) at the position-3664; and 3) substitution of cytosine (c) for adenine (a) at position 3769.