Prognostic factors in cutaneous T-cell lymphoma
2009
Cutaneous T-cell lymphoma (CTCL) are a heterogeneous group of neoplasms of skin-homing T cells that show considerable variation in clinical presentation, histological appearance, immunophenotype and prognosis. In recent classification schemes (WHO-EORTC; WHO 2008) roughly three categories of CTCL can be distinguished: (1) the group of classical CTCL, including mycosis fungoides (MF, variants or subtypes of MF (folliculotropic MF; pagetoid reticulosis; granulomatous slack skin) and Sezary’s syndrome (SS); (2) the group of primary cutaneous CD30-positive lymphoproliferative disorders (CD30+ LPD); and (3) a group of rare often aggressive cutaneous T/NK cell lymphomas, including subcutaneous panniculitis-like T-cell lymphoma (SPTCL), extranodal NK/T-cell lymphoma, nasal type, and primary cutaneous peripheral T-cell lymphoma, not otherwise specified (PTL, NOS) as well as some rare subtypes of PTL, NOS.1,2
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