Synthesis and acetyl cholinesterase inhibitory activity of new oxazole, 1, 2, 4 - triazole derivatives bearing carbamazepine as nucleus

A novel series of oxazole and 1,2,4-triazole compounds were synthesized by using carbamazepine as nucleus. The desired molecules were obtained by reaction of cyclization. The structure of the synthesized compounds were clarified using Fourier Transform Infrared spectra copy (FTIR), 1H NMR, and Mass Spectrometry spectral data. Most of derivatives were tested for their activity compared with standards drug. The inhibitor activity of the compounds against Acetyl Cholinesterase enzyme was evaluated. Most of the compounds exhibited more selective inhibitory activity towards Acetyl Cholinesterase at atime when we observed the compound A4 shows high selectivity against AChE.