Lamotrigine-induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)

A 59-year-old woman was transferred from another hospital for evaluation of fever and systemic rash. The patient stated that she noticed the morbilliform rash, 3 weeks earlier, diffusely throughout her body, sparing her palms and soles. Her primary care provider started her on levofloxacin 500 mg daily. She took no other medications. The rash progressed in the next 2 weeks with subsequent desquamation and painful, erythaematous blister formation. She also reported of systemic symptoms including malaise, fatigue and dyspnoea. She revealed that 3 weeks prior to onset of the rash, she was started on lamotrigine and was taking 50 mg daily at the time of her presentation. …