Coordinated cell-shape changes control epithelial movement in zebrafish and Drosophila
2006
Epithelial morphogenesis depends on coordinated changes in cell shape, a
process that is still poorly understood. During zebrafish epiboly and
Drosophila dorsal closure, cell-shape changes at the epithelial
margin are of critical importance. Here evidence is provided for a conserved
mechanism of local actin and myosin 2 recruitment during theses events. It was
found that during epiboly of the zebrafish embryo, the movement of the outer
epithelium (enveloping layer) over the yolk cell surface involves the
constriction of marginal cells. This process depends on the recruitment of
actin and myosin 2 within the yolk cytoplasm along the margin of the
enveloping layer. Actin and myosin 2 recruitment within the yolk cytoplasm
requires the Ste20-like kinase Msn1, an orthologue of Drosophila
Misshapen. Similarly, in Drosophila , actin and myosin 2 localization
and cell constriction at the margin of the epidermis mediate dorsal closure
and are controlled by Misshapen. Thus, this study has characterized a
conserved mechanism underlying coordinated cell-shape changes during
epithelial morphogenesis.
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