NF-κB in Human Cancers

Twenty years since their discovery, our knowledge regarding the specific role of NF-κB proteins in particular tumor types, the interaction of these proteins with other transcriptional regulators in the nucleus, and our ability to tract and abrogate NF-κB activity, effectively and specifically, remain the subject of intense research efforts in cancer therapy. While NF-κB activity is the principle subject of this chapter and the target of several early clinical trials conceptually aimed at transcriptional regulation, other transcription factors also are potential targets for therapy. Understanding the relationship between NF-κB activity with other, parallel and interacting signaling pathways, is essential to development of effective and safe targeted therapies in cancer treatment.