Regulatory Effects of a Pea-Derived Peptide Leu-Arg-Trp (LRW) on Dysfunction of Rat Aortic Vascular Smooth Muscle Cells against Angiotensin II Stimulation.
2020
Vascular oxidative
stress, inflammatory response, and proliferation
are crucial mediators of vascular dysfunction which contribute to
the pathology of hypertension. A tripeptide, LRW (Leu-Arg-Trp), was
characterized from pea protein legumin, and its previously studied
isomer IRW (Ile-Arg-Trp) was reported to exhibit antihypertensive
activity via activation of angiotensin-converting enzyme 2. The objective
of the current study was to explore the effects of LRW on vascular
stress in vascular smooth muscle cells (VSMCs) under angiotensin II
(Ang II)-induced cellular stress. LRW treatment could decrease Ang
II-triggered superoxide production, inflammation, and proliferation
in VSMCs. The abovementioned advantageous effects appeared to involve
the upregulation of the ACE2-Ang-(1–7)-MasR axis and modulation
of the nuclear factor-κB pathway. These findings specified the
prospective role of LRW as a functional food ingredient or nutraceutical
in the prevention of cardiovascular diseases, particularly hypertension
and vascular damage.
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