Antibacterial and anti-phytopathogenic substances from the insect pathogenic fungus Gibellula sp. BCC36964

Abstract Four new compounds ( 1 – 4 ), which were (−)-( 7R )-7- O -methylsydonic acid, gibellulic acid, gibellulins A and B, together with 14 known compounds ( 5 – 17 and orcinol) were isolated from the insect pathogenic fungus, Gibellula sp. BCC36964. The chemical structures were elucidated by employing NMR spectroscopic techniques, physico-chemical data, and chemical method. These compounds were evaluated for the biological activities including anti-bacterial, anti-phytopathogenic, anti- Herpes simplex virus-type 1 activities, and cytotoxicity against both cancerous (MCF-7, KB, NCI-H187) and non-cancerous (Vero) cells.