Literature Analysis on Sodium Hyaluronate After Entering the Market

OBJECTIVE:To have a systematic analysis of literature on Sodium hyaluronate(SH) for its rational use.METHODS:The articles published in China from 1994 to 2005 were retrieved in CJFD and Wanfang Database put into SPSS package for statistical analysis.RESULTS:285 articles were acquired by literature searching and distributed in 118 journals.Clinical evaluation was distributed on orthopedics(63.2%) and ophthalmology(19.6%).The methods of evaluation were mainly the control study(14.4%) and no control study(64.2%).The thesis quality of literature was 3rd(15.8%) and 4th(63.2%).78% of the articles had less than 100 examples.5 articles had more than 300 examples.CONCLUSION:The evaluation papers cannot objectively assess the efficacy and safety of Sodium hyaluranate because of poor quality.