c--fos expression within PVN and NTS of the rat induced by gastric ischemia/reperfusion injury

Aim: To investigate the effect of paraventricular nucleus (PVN) stimulation and the c-fos expressione within PVN and nucleus tractus solitarius (NTS) of the rat following gastric ischemia/reperfusion injury (GI/RI). Methods: The rat celiac artery was clamped for thirty minutes and reperfused for sixty minutes,using Fos immunohistochemical method (ABC method) examined the c-fos expression within PVN and NTS. Results: ① Both electrical and chemical stimulation of the PVN obviously attenuated the GI/RI. ② Bilateral electrolytic lesion of NTS could elimilate the protective effect of electrical stimulation of the PVN. ③The Fos-like immunoreactive neurons were increased in bilateral PVN and NTS by GI/RI. Conclusion: The function of PVN and NTS could be affected by the GI/RI noxious stimulation. PVN,NTS were involved in the regulation of GI/RI.