Clinical observation of patients with advanced esophageal caner treated with pemetrexed and oxaliplatin.

Objective To evaluate the efficacy and the side effects of the regimen of pemetrexed combined with oxaliplatin in the treatment of advanced esophageal cancer.Methods Sixty-six patients with advanced esophageal cancer were enrolled and randomly divided into treatment group and control group.Treatment group:pemerexed 500mg/m2,d1;oxaliplatin 120 mg/m2,d1;with 21 days one cycle.Control group:5-Fu 500mg/m2,d1-5;CF 0.2,d1-5;DDP 80mg/m2,divided into 3 days;with 21 days one cycle.Results The CR rate of treatment group was 6.3% and RR was 68.8%,while 2.9% and 44.1% respectively in control group.Compared with control group,the CR rate of treatment group had no significant difference(P0.05);while RR had significant difference(P=0.044).Compared with control group,the treatment group's incidence of leukopenia(P0.05),nausea and vomitting(P=0.024)and diarrhea(P=0.032)were lower,while the incidence of neuropathy(P=0.000) was higher.Conclusions It is safe and effective to treat patients with advanced esophageal cancer with pemetrexed and oxaliplatin