СОСТОЯНИЕ КЛЕТОЧНОГО ЗВЕНА ИММУНИТЕТА ПРИ АНЕМИЯХ ХРОНИЧЕСКИХ ЗАБОЛЕВАНИЙ РАЗЛИЧНОГО ГЕНЕЗА

Objective – to research the cellular immunity in anemia of chronic diseases of various origin. Materials and methods. The studies included 276 women at the age from 16 to 60. 79 persons were almost healthy and were included into the control group. 197 patients demonstrated anemia of chronic diseases. Anemia at the background of autoimmune connective tissue diseases (rheumatoid arthritis) was diagnosed in 125 women, anemia of chronic diseases in bacterial infections (chronic tonsillitis, bacterial endocarditis, chronic pyelonephritis) – in 72. Results. The patients with anemia in rheumatoid arthritis and in infectious-inflammatory processes demonstrated the decrease in the total number of CD3+ CD19-cells in the peripheral blood by means of the population CD3+CD4+-cells. The level of cytotoxic CD3+CD8+-cells did not differ from the level in the healthy persons. Conclusion. The patients with anemia of chronic diseases demonstrate the evident changes in the cellular immunity, indicating the presence of imbalance in the system of T-cells in combination with the depressed levels of the natural (mediated by NK-cells) cytotoxicity in patients with rheumatoid arthritis. At the background of rheumatoid arthritis with anemia of chronic diseases, the level of regulatory T-cells (they play their significant role in suppression of excessive inflammatory response and autotolerance) decreases significantly that may be the predictor of development of anemic syndrome.