Endoluminal Management of Gastroparesis

Gastroparesis is a functional disorder of the stomach defined as delayed gastric emptying without a clear mechanical obstruction. Despite the increasing prevalence of gastroparesis, the available treatment options remain limited and generally ineffective. For the most severe cases, procedural approaches to this problem are becoming progressively more focused on minimally invasive and endoscopic techniques that are comparable to more invasive surgical procedures. Endoscopic treatment ranges from nutritional support to pyloric-directed therapies including the application of botulinum toxin, dilation, and stenting. More recently, the gastric per oral endoscopic myotomy (G-POEM) or per oral pyloromyotomy (POP) has demonstrated promising results. As a newer technique, it has demonstrated promising results in terms of safety and subjective and objective clinical improvement. As further long-term data and studies are completed, endoluminal treatment options may shift the treatment paradigm and outcomes for patients with gastroparesis.