Approach to systemic lupus erythematosus and skin lesions

Abstract Systemic lupus erythematosus (SLE) is a chronic, autoimmune disease that involves a broad spectrum of symptoms. The underlying cause of LE is unknown but the etiology is thought to be multifactorial and polygenic. Although it can occur in both genders, it has a higher incidence in women, commonly around 30 years of age. The cutaneous manifestations of lupus are pleomorphic. Various cutaneous manifestations of LE are divided into LE-specific and LE-nonspecific skin diseases based on histological criteria. Treatment is based on preventive measures, reversal of inflammation, prevention of damage to target organs and relief of adverse events due to pharmacological therapy. In this review, clinical signs, especially skin manifestations of SLE, diagnostic criteria and treatment options have been discussed. Keywords: cutaneous lupus erythematosus, systemic lupus erythematosus, skin manifestations, therapy Ozet Sistemik lupus eritematozus (SLE), genis spektrumda semptomlari barindiran, kronik otoimmun bir hastaliktir. Lupus eritematozusun (LE) nedeni tam olarak bilinmemektedir fakat etiyoloji multifaktoryel ve poligenik olabilir. Her iki cinsiyeti etkileyebilse de ozellikle 30 yas civari kadinlarda insidansi daha yuksektir. Lupusun kutanoz bulgulari polimorfiktir. Lupusun kutanoz bulgulari histolojik kriterlere gore lupusa spesifik ve lupusa spesifik olmayan lezyonlar olarak ayrilmaktadir. Tedavi, koruyucu onlemler, inflamasyonun baskilanmasi, hedef organlardaki hasarin onlenmesi ve farmokolojik tedaviye bagli yan etkilerin azaltilmasina dayalidir. Bu derlemede, klinik bulgular, ozellikle LE’un kutanoz bulgulari, tani kriterleri ve tedavi secenekleri tartisilmistir. Anahtar sozcukler: kutanoz lupus eritematozus; sistemik lupus eritematozus; deri bulgulari; tedavi