The Study on the Antifungal Activities of Novel Derivatives of Indole, Benzofuran and Dihydropyrimidine against Candida, Aspergillus and Dermatophytes Species by Broth Micro-Dilution Method

Antifungal drugs are one of the medicines group that have the most increasing use in the past few years in human medicine sciences, especially with the development of AIDS epidemic and immunosuppressed diseases. In this line researchers have concentrated the development of new antifungal drugs that have less toxicity and more effective. The aims of this study are synthesis a few numbers of new derivatives of indole, benzofuran and dihydropyrimidine and all these products were evaluated for in vitro evaluation antifungal activity against various species of Candida, Aspergillus, and Dermatophyte by Broth Microdilution method. They also were investigated against exophiala dermatitidis, Pseudallescheria boydii, Penicillium marneffei, Cryptococcus neoformans and several species of bacteria, including Staphylococcus aureus, Escherichia coli, and Enterobacter faecalis. The obtained results were shown that some of them had outstanding effects. This research have also revealed that among the various synthesised compounds with different Structures, benzofuran derivatives were shown the best antifungal activities, while the indole and dihydropyrimidine analogues had no significant antifungal effect.