Genetic Alterations in Colorectal Carcinoma Detected by Comparative Genomic Hybridization

Background/Aims: Comparative genomic hybridization (CGH) is a new powerful technique for the molecular cytogenetic analysis of cancer. Methods: Twenty-five colorectal carcinomas were screened for chromosomal aberrations using CGH. Results: All carcinomas had chromosomal aberrations, and the mean number of chromosomal aberrations per tumor was 5.3. The cases of chromosomal gains were more common than the cases of chromosomal losses. The cases of amplification of 7q region, which contains locus of c-met, was significantly higher in stage III and IV than in stage I and II (p