Short article: Association between liver fibrosis and hepatitis E seroprevalence among HIV-positive individuals in Nepal
2019
Objective Hepatitis E virus (HEV) seropositivity may confer an increased risk of liver fibrosis in immunosuppressed individuals.
We studied this effect in HIV-infected individuals in Nepal, a country hyperendemic for HEV.
Participants and methods We prospectively evaluated 200 HIV-positive individuals. Serum samples were tested for
components of fibrosis scores and cytokeratin-18.
Results Of 200 patients, 43% were HEV-immunoglobulin G + . The mean fibrosis-4 score was 8.02 in the HEV-positive and
1.17 in the HEV-negative group (P<0.001). The mean nonalcoholic fatty liver disease score was 2.12 in the HEV-positive and
− 2.53 in the HEV-negative group (P= 0.02). The mean aminotransferase-platelet ratio index score was 0.37 in the HEV-positive
and 0.38 in the HEV-negative group (P=0.9). The mean cytokeratin-18 levels were 119.9 in the HEV-positive group and 158.6 in
the HEV-negative group (P =0.08).
Conclusion We found higher fibrosis-4 and nonalcoholic fatty liver disease scores in HEV-HIV-positive individuals, suggesting
an increased liver fibrosis profile in this group. Further studies using liver stiffness measurements should be carried out. Eur J
Gastroenterol Hepatol 31:503–505
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