a case of ccr4 positive localized primary atll of the bone

Abstract A 73-year old man visited our Hospital with the knee pain. X-ray showed an osteolytic lesion. A biopsy revealed the large atypical lymphocytes. Southern blotting revealed the HTLV-1 proviral DNA integration. PET-CT revealed no abnormalities other than the multiple bone lesions. There was no evidence of infiltration into the peripheral blood, bone marrow or central nervous system. He was diagnosed as a localized primary ATLL of the bone. he was started on CHOP, mLSG15,lenalidomide and mogamulizumab. He developed resistance to these treatments. He was detected as having hypercalcemia. Localized primary ATLL of the bone with multiple bone lesions carry a poor prognosis. Keywords Adult T-cell leukemia/lymphoma; Primary lymphoma of the bone; CCR4; Chemotherapy; Lenalidomide; Mogamulizumab