Transcriptional programming of dendritic cells for enhanced MHC class II antigen presentation

Bryan Vander Lugt,Aly A. Khan,Jason A. Hackney,Smita Agrawal,Justin Lesch,Meijuan Zhou,Wyne P. Lee,Summer Park,Min Xu,Jason DeVoss,Chauncey J. Spooner,Cecile Chalouni,Lélia Delamarre,Ira Mellman,Harinder Singh

Transcriptional programming of dendritic cells for enhanced MHC class II antigen presentation

2014

Bryan Vander Lugt
Aly A. Khan
Jason A. Hackney
Smita Agrawal
Justin Lesch
Meijuan Zhou
Wyne P. Lee
Summer Park
Min Xu
Jason DeVoss
Chauncey J. Spooner
Cecile Chalouni
Lélia Delamarre
Ira Mellman
Harinder Singh

Dendritic cell (DC) subsets show functional specialization. Singh and colleagues demonstrate that the transcription factor IRF4 enhances antigen presentation by MHC class II in CD11b+ DCs to promote the priming of CD4+ effector T cells.

Keywords:

Dendritic cell
Immunology
Cell biology
MHC class II antigen
MHC class I
Antigen presentation
Biology
Cellular differentiation
MHC class II
Antigen processing
Effector

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