EFFECT OF HIGH CALCIUM INTAKE ON BLOOD PRESSURE AND INTRACELLULAR pH, Na￣+-H￣+ EXCHANGE ACTIVITY IN STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS

Effect of high calcium(3%) intake on bital pressure and intracellular pH, Na+-H+ exchange activity, cytosolic free calcium concentration in stroke-prone spontaneously hypertensive rats (SHRSP-Ca) is compered with sex-, ag-matched SHRSP and WKY rats without high calcium intake. The results showed that high calcium intake significantly suppressed increase in blood pressure and decreased cytosolic free calcium concentration after it was given to SHRSP-Ca for 6 weeks, while plasma calcium was increased. The intracellular pH tended to be in the normal range of WKY ratS. Na+-H+ exchange activity was slightly decreased. Correlationship between blood pressure and intracellular PH, Na+-H+ exchange activity and cytosolic free calcium concentration were discussed.